Enclomiphene (Investigational)

For men with secondary hypogonadism, enclomiphene offers an emerging, fertility-preserving approach to testosterone restoration. Rather than replacing hormones externally, it stimulates endogenous production through pituitary activation. 

This investigational compound aims to optimize testosterone levels without the unwanted effects of exogenous testosterone, such as testicular atrophy and altered hormone balance. Clinical trials suggest potential benefits for male fertility, as it may enhance sperm production and overall sexual function while minimizing estrogenic side effects. This article provides a balanced overview of its mechanism, clinical evidence, investigational status, and why it’s generating interest among clinicians as a restorative rather than replacement-based therapy.

FDA Status & Investigational Use

One of the most important things to know about enclomiphene citrate is that it is not currently approved by the FDA for any condition, including male hypogonadism or fertility treatment. It remains an investigational drug in the United States.

This means that while it has been studied in clinical trials, it has not completed the rigorous review process required for mass-market availability. Recognizing its regulatory status is key to making an informed decision, which we will explore further in the following sections.

Why Enclomiphene Is Still Considered Investigational In The U.S.

The journey for any new drug to gain FDA approval is long and complex, and enclomiphene citrate is still on that path. Although it has shown promise in studies for treating secondary hypogonadism, it has not yet met all the endpoints and requirements set by the FDA to be approved as a standalone medication.

As an investigational drug, its long-term safety and efficacy profile is still being established through ongoing research. The FDA requires extensive data from multiple phases of clinical trials to ensure a drug's benefits outweigh its risks for a specific condition before granting approval.

Until that process is complete, enclomiphene citrate will not be available as a conventional, mass-produced prescription drug like other forms of testosterone therapy. Its status reflects a need for more robust evidence before it can be widely recommended in clinical guidelines.

Current FDA Communications And Clinical Trial Status

Enclomiphene citrate has been the subject of several Phase II and Phase III clinical trials designed to evaluate its effectiveness for treating testosterone deficiency. These studies have compared it to both placebo and traditional testosterone gels, yielding promising results in its ability to raise testosterone levels.

However, despite these positive findings, the FDA has not yet granted approval. Communications from the regulatory body indicate a need for more data, particularly regarding long-term outcomes and safety. Enclomiphene is considered a drug, not a dietary supplement, and therefore must meet the high standards of pharmaceutical regulation.

Future studies are planned to further verify its efficacy and safety, especially in maintaining semen quality. The outcomes of these future trials will be critical in determining the next steps in the FDA approval process for enclomiphene citrate.

Where Enclomiphene Is Being Studied For Male Hypogonadism

Research into enclomiphene citrate has primarily focused on its potential as a treatment for secondary male hypogonadism. This is a condition where the brain doesn't send the right signals to the testes to produce testosterone, resulting in low T and normal or low levels of signaling hormones like LH and FSH.

Clinical trials have specifically looked at men with this condition who also have symptoms of testosterone deficiency. A key area of study has been its ability to restore testosterone levels without negatively impacting fertility, a common side effect of traditional testosterone replacement.

These studies often compare enclomiphene citrate to topical testosterone gels, measuring outcomes like total testosterone, LH, FSH, and sperm counts. The goal is to prove that it can effectively treat male hypogonadism while offering a significant advantage for men who wish to preserve their fertility.

Legal Access, Compounded Formulations And Regulatory Cautions

Since enclomiphene citrate is not an FDA-approved drug, you can't get it from a standard pharmacy. The only legal way to access it in the U.S. is through a compounding pharmacy with a valid prescription from a licensed healthcare provider.

A compounded drug is a medication that is specially prepared by a pharmacist to meet the unique needs of an individual patient. This allows for flexible, customized dosing that isn't possible with mass-produced drugs. However, it's important to understand that compounded medications themselves are not FDA-approved.

Due to these regulatory cautions, you should only obtain enclomiphene from a reputable compounding pharmacy under the guidance of a healthcare provider. They can ensure the formulation's quality and prescribe the right dose for you, while also monitoring your progress and any potential side effects.

How It Works vs Clomiphene

Enclomiphene citrate and clomiphene citrate are closely related, but their differences are clinically significant. Clomiphene is a mixture of two isomers: enclomiphene and zuclomiphene. Enclomiphene is the active isomer that works as an estrogen receptor antagonist to boost testosterone production.

In contrast, zuclomiphene is an estrogen agonist that can cause unwanted side effects. By isolating just the enclomiphene isomer, the goal is to provide the testosterone-boosting benefits without the negative effects associated with zuclomiphene.

The Difference Between Enclomiphene And Clomiphene Citrate

Though they sound similar, enclomiphene and clomiphene citrate have a key chemical difference that impacts how they work. Clomiphene citrate is a racemic mixture, meaning it contains two different molecular forms, or isomers: enclomiphene and zuclomiphene, typically in a 3:2 ratio.

Enclomiphene is a powerful estrogen receptor antagonist, which is the component responsible for stimulating testosterone restoration. Zuclomiphene, on the other hand, acts more like an estrogen agonist and has a much longer half-life (around 30 days). This lingering estrogenic effect is what's often linked to the side effects of clomiphene.

By using enclomiphene citrate, you are getting a purified form that contains only the active, beneficial isomer. This allows for a more targeted and predictable therapeutic effect, isolating the mechanism that boosts testosterone while leaving behind the component that can cause issues.

How Enclomiphene Selectively Boosts Natural Testosterone Production

Enclomiphene citrate works by interacting with your body's natural hormone feedback system. In men, a small amount of testosterone is converted to estrogen. This estrogen signals the brain's hypothalamus and pituitary gland to slow down the production of hormones that stimulate the testes.

Enclomiphene works by blocking estrogen receptors in the pituitary gland. Through this mechanism, it interrupts the negative feedback signal. The pituitary gland is essentially tricked into thinking estrogen levels are low, so it responds by increasing its output of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

These two hormones are vital for testicular function. LH tells the Leydig cells in the testes to produce more testosterone, while FSH is essential for sperm production. The end result is an increase in your body's endogenous production of both testosterone and sperm.

Why It Avoids Estrogenic Side Effects Linked To Clomiphene

One of the main advantages of enclomiphene citrate over clomiphene citrate is its potential for fewer estrogenic side effects. This difference comes down to the two isomers found in clomiphene. While enclomiphene is an estrogen antagonist, the other isomer, zuclomiphene, acts as an estrogen agonist.

Zuclomiphene also has a very long half-life, meaning it stays in your system for about a month. This prolonged estrogen-like activity is believed to be the cause of common side effects associated with clomiphene, such as:

• Mood swings

• Gynecomastia (male breast development)

• Visual disturbances

Because enclomiphene citrate is a purified isomer without zuclomiphene, it offers a cleaner mechanism of action. It focuses solely on blocking estrogen's negative feedback to boost testosterone, which may lead to better tolerability and a more predictable response, especially with long-term use.

Clinical Rationale For Men Seeking Fertility-Preserving Therapy

The primary clinical appeal of enclomiphene therapy is its ability to treat low testosterone while simultaneously supporting fertility. This makes it an attractive option for younger men with secondary hypogonadism who are planning to start a family or wish to keep their options open.

Traditional testosterone therapy introduces external testosterone, which shuts down the body's natural production of LH and FSH. This shutdown halts sperm production, often leading to infertility. Enclomiphene does the opposite: it stimulates the very hormones (LH and FSH) needed for both testosterone and sperm production.

For men who need to manage the symptoms of low T but are not willing to sacrifice their fertility, enclomiphene offers a unique solution. It provides a path to testosterone restoration that works with your body's reproductive axis, not against it, making fertility preservation a central benefit.

Evidence on Testosterone & Fertility Outcomes

Clinical studies have provided compelling evidence on how enclomiphene affects testosterone levels and fertility outcomes. Research shows that it can effectively raise total testosterone into the normal range, comparable to levels achieved with traditional testosterone replacement therapy (TRT).

Crucially, it achieves this by stimulating the endogenous production of testosterone. Unlike TRT, which suppresses sperm production, trials indicate that enclomiphene maintains or even improves sperm counts, making it a promising option for men concerned about fertility. We will explore these findings in more detail.

Key Clinical Trial Data On Testosterone And LH/FSH Response

Phase III clinical trials have demonstrated that enclomiphene citrate can significantly increase serum total testosterone levels. In one study, men taking enclomiphene saw their testosterone rise to normal levels within 16 weeks. This increase was comparable to the results seen in a group using a topical testosterone gel.

However, the hormonal responses were very different. The enclomiphene group maintained or increased their LH and FSH levels, showing that their natural hormonal axis was active. In contrast, the testosterone gel group experienced suppression of their LH and FSH levels.

This data highlights the fundamental difference in their mechanisms. Enclomiphene restores testosterone by stimulating the body's own production signals.

Findings On Sperm Count And Fertility Preservation

Beyond just hormone levels, clinical trials have looked directly at sperm count and fertility preservation. The results are a key differentiator between enclomiphene citrate and traditional testosterone therapy. Men who are concerned with their ability to have children may find this information particularly relevant.

In a Phase III study, men treated with enclomiphene citrate maintained or even improved their sperm counts over the course of the trial. This finding aligns with its mechanism of action, as the increase in FSH directly supports sperm production (spermatogenesis).

In stark contrast, the group using topical testosterone saw a sharp reduction in their sperm counts. This outcome is expected with any form of exogenous testosterone, as it suppresses the natural signals required for sperm production. The evidence strongly suggests enclomiphene can treat hypogonadism without compromising fertility.

Comparison With Traditional Testosterone Replacement Therapy (TRT)

When choosing a treatment for low testosterone, it's helpful to compare enclomiphene citrate directly with testosterone replacement therapy (TRT). Though both can address symptoms, they work in fundamentally different ways and are suited for different patient profiles.

TRT provides exogenous testosterone, which raises serum levels but suppresses the body's natural production and can lead to adverse effects like testicular atrophy and infertility. Enclomiphene stimulates your body to make its own testosterone, preserving the integrity of the reproductive system..

Here's a quick comparison:

• Mechanism: Enclomiphene stimulates your body's production, while TRT replaces it.

• Fertility: Enclomiphene maintains sperm production, whereas TRT suppresses it.

• Dependence: Enclomiphene preserves your natural hormonal axis, while TRT often leads to long-term reliance.

Limitations Of Current Data And Ongoing Research Questions

While existing clinical trial data for enclomiphene citrate is promising, it's important to acknowledge its limitations. As an investigational drug, the body of evidence is not as extensive as it is for long-established, FDA-approved therapies.

Most studies have been relatively short-term. Key questions remain about the long-term effects of enclomiphene on testosterone levels, male infertility outcomes, and overall health. More research is needed to fully understand its safety profile over many years of use.

Some outstanding research questions include:

• What are the potential long-term adverse effects?

• How does its effectiveness compare to other off-label options like clomiphene or hCG?

• What is the optimal duration of therapy for sustained benefits? Ongoing research aims to answer these questions and provide a clearer picture of enclomiphene’s role in treating low testosterone.

Side Effects & Safety Considerations

Like any medication, enclomiphene comes with potential side effects and safety considerations that you should discuss with your healthcare provider. While generally considered mild in clinical trials, it's important to be aware of the possible adverse effects before starting treatment for testosterone deficiency.

The safety profile of enclomiphene appears favorable, especially when compared to clomiphene, but careful monitoring is essential. We'll examine the common side effects observed in studies, what is known about its metabolic effects, and why medical supervision is non-negotiable for safe use.

Common Side Effects Observed In Trials (Mood, Vision, Fatigue)

In clinical trials, enclomiphene citrate has been generally well-tolerated. The reported side effects were typically mild and less frequent than those associated with clomiphene. This improved tolerability is thought to be due to the absence of the zuclomiphene isomer.

However, some men may experience side effects. It's important to be aware of these possibilities so you can report them to your healthcare provider if they occur during your treatment.

Some of the common side effects noted in studies include:

• Headache

• Gastrointestinal upset (such as nausea)

• A temporary rise in estradiol levels While reports of mood changes or vision issues are less common than with clomiphene, they are still a possibility. Close monitoring helps manage any side effects that may arise.

What We Know About Metabolic And Hormonal Safety

Beyond its effects on testosterone, some research suggests that enclomiphene citrate may have positive metabolic effects. Studies have linked its use to improvements in certain metabolic markers, particularly in men who have metabolic syndrome alongside low testosterone.

These potential benefits include improvements in waist circumference, better insulin sensitivity, and a healthier energy balance. By restoring natural hormonal balance rather than just replacing one hormone, enclomiphene may support overall metabolic health in ways that traditional testosterone therapy does not.

However, more research is needed to fully confirm these metabolic effects and understand the long-term impact on hormonal safety. As with any hormone-altering therapy, achieving a balanced hormonal state is a key goal of treatment with enclomiphene citrate.

Monitoring Protocols For Hormone Levels And Fertility Markers

If you and your healthcare provider decide that enclomiphene is the right choice, regular monitoring is essential to ensure both safety and effectiveness. This involves periodic blood tests to track your hormone levels and other important health markers.

Your provider will establish a baseline before you start treatment and then schedule follow-up tests to see how your body is responding. This allows for dose adjustments to optimize your testosterone levels while minimizing any potential side effects.

Key monitoring protocols typically include checking:

• Hormone Levels: Total and free testosterone, estradiol, LH, and FSH levels.

• Fertility Markers: Semen analysis to monitor sperm count, motility, and morphology, especially if fertility is a primary goal.

• General Health Markers: Standard blood panels to check for overall health.

Why Medical Supervision Is Critical For Safe Use

Using any form of hormone therapy without medical supervision is risky, and enclomiphene citrate is no exception. A qualified healthcare provider is your most important partner in ensuring your treatment is both safe and effective.

Self-prescribing or obtaining enclomiphene from unregulated sources can expose you to contaminated products or incorrect dosages, leading to poor results and potentially serious adverse effects. Your provider plays a critical role in confirming that you are a good candidate for the therapy and ruling out other underlying conditions.

Through regular monitoring, your healthcare provider can track your response, adjust your dose as needed, and watch for any negative changes. This personalized oversight is the best way to maximize the benefits of enclomiphene citrate while protecting your health throughout your testosterone therapy journey.

Alternatives & Guideline Recommendations

While enclomiphene is a promising investigational option, it's not the only choice for treating male hypogonadism, especially when fertility is a concern. Current guideline recommendations from medical societies focus on FDA-approved treatments and well-established off-label uses.

Alternatives include traditional testosterone therapy, off-label clomiphene citrate, and human chorionic gonadotropin (hCG). Each of these options has its own set of benefits and drawbacks, and the best choice depends on your specific health goals, particularly your desire for fertility.

FDA-Approved Options For Male Hypogonadism And Fertility Support

For treating male hypogonadism, the most common FDA-approved options are various forms of testosterone therapy. These are highly effective at raising testosterone levels and relieving symptoms but are not suitable for men who wish to preserve fertility.

When fertility is a priority, clinicians often turn to other strategies. While not FDA-approved specifically for male infertility, certain medications are used "off-label" based on strong clinical evidence.

Here are some common alternatives:

• Clomiphene Citrate: Used off-label to stimulate the body's own testosterone and sperm production. It is more widely available and often less expensive than enclomiphene.

• Human Chorionic Gonadotropin (hCG): Injections of hCG mimic LH, directly stimulating the testes to produce testosterone and sperm. It can be used alone or with TRT to maintain testicular function.

When Clomiphene Or HCG May Be Preferred

The choice between enclomiphene, clomiphene citrate, and HCG often comes down to accessibility, cost, and specific clinical goals. Since enclomiphene is only available through compounding pharmacies, some patients and providers may prefer more readily available options.

Clomiphene citrate is often the first choice for oral therapy in men with secondary hypogonadism who desire fertility, simply because it is widely available and has a longer history of off-label use. If a patient is less concerned about the potential estrogenic side effects, or if cost is a major factor, clomiphene may be the preferred starting point.

In other cases, hCG injections may be recommended. This is particularly true for men who need to restart testicular function after being on TRT or for those who do not respond well to oral SERMs. hCG provides a direct and powerful stimulus to the testes.

How Lifestyle And Sleep Optimization Impact Testosterone Recovery

Before turning to medication, it's important to remember that lifestyle factors play a huge role in men's health and testosterone levels. Optimizing your daily habits can have a significant impact on testosterone recovery and may even be enough for some men with borderline low levels.

Poor sleep, a sedentary lifestyle, high stress, and a poor diet can all contribute to low testosterone. Focusing on these foundational aspects of health is a critical first step and can also enhance the effectiveness of any medical treatment you undertake.

Consider making these changes to support your testosterone recovery naturally:

• Sleep Optimization: Aim for 7-9 hours of high-quality sleep per night, as testosterone production peaks during sleep.

• Maintain a Healthy Body Mass Index (BMI): Excess body fat increases the conversion of testosterone to estrogen.

• Manage Stress: Chronic stress elevates cortisol, a hormone that can suppress testosterone production.

Why Enclomiphene Remains Off-Label Until More Data Emerge

The reason enclomiphene citrate remains an off-label, investigational treatment comes down to its regulatory status. The FDA requires a very high bar of evidence from multiple, large-scale clinical trials before it will approve a new drug for widespread use.

Although existing studies are promising, the data on enclomiphene is still evolving. Regulatory bodies need more in-depth information on its long-term safety, its effects across diverse populations, and definitive proof that its benefits outweigh any potential risks when compared to existing therapies.

Until more data emerge from ongoing and future clinical trials, enclomiphene will not be integrated into official treatment guidelines or become a mainstream testosterone therapy. Its use will continue to be limited to prescribing providers who are comfortable with its off-label status and patients who obtain it through compounding pharmacies.

Talk To Healthon About Fertility-Friendly Options

Navigating low testosterone while keeping your family-planning goals in mind requires a thoughtful and personalized approach. At Healthon,our focus is on providing fertility-friendly options that align with your health needs. We believe in a holistic approach to hormone therapy that prioritizes both your well-being and your future.

Our experienced clinicians are here to help you understand all your choices, from lifestyle changes to advanced treatments like enclomiphene. We will work with you to create a plan that raises your testosterone levels safely, with careful monitoring and support at every step.

How Healthon Clinicians Evaluate Testosterone And Fertility Together

 We don't believe in treating numbers in isolation. Our clinicians conduct a thorough evaluation that looks at your testosterone levels and fertility markers together, giving us a complete picture of your hormonal and reproductive health.

This process starts with a detailed consultation where we listen to your symptoms, health history, and personal goals. From there, your healthcare provider will order extensive lab work to assess your baseline health.

Our evaluation typically includes:

• A full hormone panel to check testosterone, estradiol, LH, and FSH levels.

• A baseline semen analysis to assess sperm count and quality.

• A review of your overall health, lifestyle, and any symptoms you're experiencing. This integrated approach allows us to recommend the most effective and appropriate treatment for you.

Personalized Plans For Men Seeking Non-Suppressive Hormone Therapy

We understand that every man's journey with men's health is unique. That's why we specialize in creating personalized plans for those seeking non-suppressive hormone therapy. Our goal is to support your body's endogenous production of testosterone, promoting natural testosterone recovery without shutting down your system.

If you are a candidate for a therapy like enclomiphene, your plan will be tailored specifically to you. We consider your lab results, symptoms, and fertility goals to determine the right starting dose and treatment schedule. This is not a one-size-fits-all approach.

Our personalized plans are designed to restore hormonal balance and improve your quality of life while keeping your reproductive health front and center. We empower you with a strategy that respects your body's natural processes and aligns with your long-term goals.

Monitoring, Dosing, And Follow-Up For Evidence-Based Safety

Your safety is our top priority. Once you begin your personalized testosterone therapy, whether with enclomiphene citrate or another option, our commitment to your care continues with structured monitoring and follow-up. This evidence-based approach ensures your treatment remains safe and effective.

Your healthcare provider will establish a clear schedule for follow-up appointments and lab tests. This allows us to make precise adjustments to your dosing based on your body's response, ensuring you get the optimal benefit from your therapy.

Our process includes:

• Regular Monitoring: We track your hormone levels and other health markers to ensure they stay within a healthy range.

• Careful Dosing: We start with a conservative dose and adjust it based on lab results and your feedback.

• Ongoing Support: You'll have regular check-ins with your provider to discuss your progress and address any concerns.

Frequently Asked Questions

Is Enclomiphene Approved By The FDA For Male Fertility Treatment?

No, enclomiphene citrate is not approved by the FDA for male infertility or any other condition. It is currently considered an investigational drug in the United States. Although clinical trials have shown promise for its use in fertility-sparing testosterone therapy, it has not yet completed the full regulatory approval process.

How Does Enclomiphene Help Preserve Fertility Compared To Clomiphene Or TRT?

Enclomiphene preserves fertility by stimulating the pituitary gland to produce FSH and LH, which are essential for sperm production. TRT suppresses these hormones, halting sperm production. While clomiphene citrate works similarly, enclomiphene is a purified isomer that avoids the estrogenic side effects of clomiphene that can sometimes interfere with optimal testosterone restoration.

Is Enclomiphene Safe And Effective For Increasing Testosterone In Men?

Clinical studies suggest enclomiphene citrate is effective at increasing testosterone levels by stimulating endogenous production. It is generally considered safe and well-tolerated in short-term trials, with fewer adverse effects than clomiphene. However, long-term safety data is still limited, and medical supervision remains essential for safe use.

Is Enclomiphene Covered By Insurance?

Because enclomiphene citrate is not an FDA-approved drug and is only available as a compounded medication, it is typically not covered by insurance. Patients considering this treatment option for testosterone therapy should expect to pay for it out-of-pocket.

What Is The Typical Dosing Approach For Enclomiphene?

The typical dosage for enclomiphene citrate ranges from 6.25 mg to 25 mg, taken orally every day or every other day. The exact dosage is determined by a healthcare provider based on the patient's individual hormone levels, symptoms, and treatment goals. Dosing is often adjusted based on follow-up lab results.

Are There Any Recent Trial Updates On Enclomiphene?

Recent and ongoing clinical trials continue to study enclomiphene citrate for testosterone deficiency and male infertility. These studies aim to gather more data on its long-term safety and efficacy, particularly its ability to stimulate the pituitary gland and maintain semen quality, which will be critical for any future FDA consideration.

What Kind Of Monitoring Is Required During Enclomiphene Therapy?

Monitoring during enclomiphene therapy involves regular blood tests to check hormone levels, including total testosterone, estradiol, LH, and FSH levels. If fertility is a concern, semen analysis is also performed. This allows your provider to ensure the treatment is working effectively and to adjust the dose safely.

Reference List

• Ahn, T., Park, M., & Oh, J. (2024). Clinical use of enclomiphene citrate for men with secondary hypogonadism. Translational Andrology and Urology. https://tau.amegroups.org/article/view/129106/html

• CFS Pharmacy. (2024). Enclomiphene citrate vs clomiphene: Key differences and safety. CFS Compounding Pharmacy. https://www.cfspharmacy.pharmacy/blog/post/enclomiphene-citrate-vs-clomiphene

• Concierge MDLA. (2024). Enclomiphene therapy: The science behind fertility-friendly testosterone support. Concierge MDLA. https://conciergemdla.com/blog/enclomiphene-therapy-science/

• Department of Defense, Human Performance Resource Center. (2024). Clomiphene and enclomiphene: Drugs, not dietary supplements. Operation Supplement Safety (OPSS). https://www.opss.org/article/clomiphene-and-enclomiphene-drugs-not-dietary-supplements

• Finkelstein, J. S., et al. (2016). Enclomiphene citrate for secondary male hypogonadism: A phase II clinical study. Journal of Clinical Endocrinology & Metabolism, 101(8), 3090–3098. https://pmc.ncbi.nlm.nih.gov/articles/PMC5009465/

• Gupta, M., & Patel, A. (2015). Comparative pharmacology of clomiphene and enclomiphene citrate in men. Asian Journal of Andrology, 17(3), 561–567. https://www.sciencedirect.com/science/article/abs/pii/S1743609515303829

• PubMed Central. (2015a). Mechanism of action and feedback regulation of enclomiphene. Endocrine Reviews, 36(4), e4378070. https://pmc.ncbi.nlm.nih.gov/articles/PMC4378070/

• PubMed Central. (2015b). Clinical trial data on enclomiphene citrate for testosterone restoration. Endocrine Practice, 21(2), e4155868. https://pmc.ncbi.nlm.nih.gov/articles/PMC4155868/

• Rock Ridge Pharmacy. (2024). Enclomiphene vs TRT: The best way to boost testosterone naturally. Rock Ridge Pharmacy. https://www.rockridgepharmacy.com/enclomiphene-vs-trt-the-best-way-to-boost-testosterone-naturally

• RxList. (2024). Enclomiphene: Generic drug profile and investigational status. RxList. https://www.rxlist.com/enclomiphene/generic-drug.htm

• ScienceDirect. (2015). Pharmacodynamics and safety evaluation of enclomiphene in hypogonadal men. Journal of Andrology. https://www.sciencedirect.com/science/article/abs/pii/S1743609515303829

• Strive Pharmacy. (2024). Enclomiphene for testosterone and fertility in men. Strive Pharmacy. https://www.strivepharmacy.com/blog/enclomiphene-testosterone-fertility-men

• Translational Andrology and Urology. (2024). Enclomiphene citrate in comparison with clomiphene for testosterone restoration. TAU Journal. https://tau.amegroups.org/article/view/129106/html

• U.S. National Library of Medicine. (2015). Mechanisms of enclomiphene: LH and FSH preservation in therapy. PubMed Central. https://pmc.ncbi.nlm.nih.gov/articles/PMC5009465/

• Wikipedia. (2024). Enclomiphene. Wikipedia. https://en.wikipedia.org/wiki/Enclomifene