Hormone Replacement in Men & Women: Combining Peptides, NAD+ & BHRT

December 04, 2025
Blog
Journal

Authors

Reviewed by Dr. Rasoul Montazeri

Triple Board Certified Physician and The Founder

Niayesh Najafi

Medical student and researcher in Health Sciences

Table of contents

A Closer Look at Integrative Hormone Optimization
Bioidentical Hormones Explained
BHRT for Men and Women: Indications and Benefits
Peptide Therapy for Hormonal and Metabolic Health
NAD+ Therapy and Its Contribution to Wellness
Novanex’s Coordinated, Physician-Supervised Protocols
Make Your Next Move with Clarity and Confidence
Frequently Asked Questions

Key takeaways

Personalized Plans: BHRT, peptides, and NAD+ tailored to individual needs.
Bioidentical Hormones: Natural, plant-based hormones vs. synthetic ones.
Peptides & NAD+: Support metabolism, energy, and cellular health.
Clinical Supervision: Treatments customized and monitored by a provider.

Medical ampoule and syringe representing peptide, vitamin, and amino-acid injectables used in integrative hormone and wellness therapy

As hormone production naturally declines with age, many people experience symptoms such as fatigue, mood changes, weight fluctuations, hot flashes, and cognitive fog that can disrupt daily life. Gaining insight into available therapies, such as bioidentical hormone replacement therapy (BHRT), targeted peptide treatments, and NAD+ support, helps clinicians and patients build personalized plans that address both the symptoms and the underlying hormonal shifts that cause them.

BHRT restores hormone levels using formulations that closely match the body’s natural hormones, allowing for individualized dosing based on lab results and health history. Peptide therapy may complement this approach by supporting metabolic health, sleep, tissue repair, or cellular signaling. NAD+ support has also gained attention for its potential role in energy production and cellular resilience, although its long-term benefits continue to be studied.

When used thoughtfully and under clinical supervision, these therapies can work together to balance hormones, reduce disruptive symptoms, and promote greater vitality. This integrative approach empowers adults at every stage of life to regain clarity, stability, and overall well-being.

A Closer Look at Integrative Hormone Optimization

Integrative hormone optimization does more than just replace hormones. This way helps make a treatment plan that is built for you. It can blend different therapies to meet your health needs and goals. A doctor will look at your hormone levels, your menopausal symptoms, and your risk factors. The plan is made just for you.

This is not a one-size-fits-all way. It uses health checks and sometimes data from clinical trials. This makes sure your treatment plan is safe and works well. The goal is to get things in balance again and help you feel better inside and out.

Bioidentical Hormones Explained

Illustration explaining the hierarchy of hormone replacement therapy including BHRT, peptides, and NAD+ as part of integrative hormone optimization

You may want to know what sets bioidentical hormones apart. Bioidentical hormones come from plant sources and are made to match the exact molecular structure of the hormones that your body makes, such as estrogen, progesterone, and testosterone. Your body can use these bioidentical hormones just like it uses its own.

Traditional hormone replacement therapy often uses synthetic hormones. These synthetic hormones do not have the same structure as the ones in your body. Some bioidentical hormones get approved by the FDA and made by drug companies. Others get made just for you at compounding pharmacies. It’s good to talk with your provider about hormone replacement, bioidentical hormones, and traditional hormone replacement therapy so you understand how they all work and what the differences are.

BHRT for Men and Women: Indications and Benefits

Bioidentical hormone therapy or BHRT helps men and women who deal with signs of changing hormones. For women, this hormone therapy can be good for handling symptoms of menopause, like hot flashes, night sweats, and vaginal dryness. Getting the right balance of hormones back can make daily life better and help support overall health.

Men who have low testosterone could also use menopausal hormone therapy. This may help with tiredness, low sex drive, and changes in mood. Besides helping with these symptoms, bioidentical hormone therapy might help lower the risk for some health conditions, like osteoporosis. It can also help with issues such as weight gain that come from hormonal changes.

Peptide Therapy for Hormonal and Metabolic Health

Peptide therapy is a strong tool in modern hormone treatments. The peptides are small chains made up of amino acids. These work as signals in your body. They tell cells and molecules what they should do. Peptides have a key role in many body functions, like making hormones and helping with how your body uses what you eat.

If you use peptide therapy as part of an overall treatment plan, it can help your body react better to changes in hormones. The peptides given are chosen for you based on your medical history and what you may need. Some of these peptides can help you get more energy, support you in losing fat, and work with other treatment options to give better results.

NAD+ Therapy and Its Contribution to Wellness

Happy man resting after workout symbolizing improved energy, strength, and vitality from optimized hormone and peptide therapy

NAD+ (nicotinamide adenine dinucleotide) is something found in every cell in your body. The body needs it to make energy and help fix cells. As you get older, your NAD+ levels go down. This can make you feel tired and have other symptoms that come with age. NAD+ therapy can help bring these levels back up, which is good for your overall health.

If you use NAD+ therapy with hormone therapies, you may see better results. It can help your cells get more energy and be stronger. This may help with problems like feeling tired or having trouble thinking, especially if you have hormonal issues. Looking at your health history can help you and your doctor decide if this is one of the treatment options for you.

Novanex’s Coordinated, Physician-Supervised Protocols

Novanex gives you a modern way to handle hormone treatments. The team puts together a plan that is watched by a doctor and uses BHRT, peptides, and NAD+ therapy all at once. The process starts with a full check of your health history and special tests.

After seeing this information, a doctor makes a treatment plan that is built just for you and your human body. The plan looks at your needs and checks safety all the time. Your dose is set to be just right, so you can reach your wellness goals. This helps you feel sure about your care.

Make Your Next Move with Clarity and Confidence

Healthcare provider consulting older patient about personalized BHRT, peptide therapy, and NAD+ treatment options

Taking control of hormone health can transform energy, mood, and overall vitality. With the right clinical guidance, personalized treatment protocols can restore balance and create lasting, meaningful improvements. Healthon clinicians partner closely with patients to evaluate hormone levels, understand symptoms, and set realistic wellness goals.

Through evidence-based approaches, such as BHRT, peptide therapy, and supportive options like NAD+, providers design safe, individualized plans tailored to each patient’s needs. This collaborative process empowers people to regain clarity, improve daily functioning, and experience renewed well-being.

If you’re ready to explore your options, Healthon’s team is available anytime to answer questions, review your health history, and guide you toward a treatment strategy that supports long-term wellness.

Frequently Asked Questions

What should I discuss with my provider before starting BHRT, NAD+, or peptide therapy?

Be ready to talk about the symptoms you have right now. You should also let them know about your own medical history and your family’s health background. Be sure to mention any health conditions you have. Let your provider know your wellness goals, too. This helps them choose treatment options in hormone replacement that fit you. You want the plan to match what you want to get and how you want to feel.

How do physicians determine the right dosage and combination of therapies?

Doctors look at your blood test results to check your hormone levels. They also go over your health history and talk with you about your symptoms. With this information, they make a treatment plan for you. This helps make sure your hormone therapy and the dose you get fits you best.

Are there any side effects or safety considerations with combined hormone modalities?

Possible side effects of hormone replacement can be feeling bloated, having changes in your mood, or getting headaches. These often go away when your body gets used to it. Your provider will look at your medical history, your health conditions, and the risk of breast cancer. This helps them lower any risks so your hormone replacement plan is safe for you.