BLOG • Journal • 13 August 2025

Mounjaro Constipation: Causes, Relief & What to Expect

Woman holding her abdomen in discomfort, representing constipation as a common gastrointestinal side effect associated with Mounjaro (tirzepatide) treatment.

Starting a weight loss journey with Mounjaro (tirzepatide) can be life-changing for people managing type 2 diabetes. But a common side effect that many people do not expect is constipation. Why does this happen? What can you do to deal with it safely without getting in the way of your main health goals?

When you take medicines like Mounjaro, they can slow down your digestive system, which may lead to potential drug interactions and increase your risk of low blood sugar. This means your bowel movements may not happen as often or as easily, especially over a longer period of time. This can make daily life hard and affect your comfort and health. Clinical trials also show constipation is one of the most common side effects of Mounjaro.

If you get this side effect, you are not alone. There are different ways to find relief. You can try changes in what you eat, lifestyle changes, or simple over-the-counter products. If your symptoms do not get better, knowing when to talk to your doctor is very important. 

Keep reading to learn how you can deal with effects of Mounjaro like constipation, how to spot the most common side effects of Mounjaro and tips on taking care of your digestive system during your weight loss journey. Find out how Healthon can help with a compounded tirzepatide option and offer you care that fits your needs.

Does Mounjaro Cause Constipation?

Infographic outlining Mounjaro side effects and their management strategies, including hydration, diet adjustments, and when to consult a healthcare provider.

Yes, constipation is one of the most common side effects of Mounjaro (tirzepatide). This drug, which is required for its approval by the Food and Drug Administration, is used to help lower blood sugar and support weight loss, particularly for individuals dealing with weight-related health issues like high blood pressure. 

It works by slowing down the digestive system, which includes slowing how fast your stomach empties. The effects of Mounjaro on the stomach often make it hard to have regular or easy bowel movements.

Mild side effects of Mounjaro usually go away as the body gets used to the drug. But clinical data has shown that constipation among the more common Mounjaro side effects can happen to up to 7% of people, and this changes with different doses. If you have long-lasting or serious stomach or bowel problems from Mounjaro, you should talk to your doctor, as this can lead to more digestive system problems.

Why Constipation Happens With Mounjaro/Tirzepatide

GIP and GLP-1 receptor agonists, like tirzepatide, help the body release more insulin and manage glucose. This makes the process of gastric emptying slower. When the stomach empties more slowly, the normal way food moves through the digestive system can get blocked. 

As a result, constipation may happen as a side effect. Clinical trials found that this side effect showed up often, so it’s important for people using these drugs to watch their digestive system and health.

This is especially key for Mounjaro users who have gastrointestinal side effects related to the given drug. Knowing how these drugs work and how they change gastric emptying helps users understand what is happening in the body. If they use good management tips, they can take care of the side effects and make their day-to-day life better.

If you are worried about the effects of Mounjaro or want to look at other choices, Healthon has some helpful information:

  • Read Healthon’s Blog on Tirzepatide Side Effects: What to Know Before Starting gives you clear details about both mild and severe side effects. It also explains what to do if you see any of these effects of Mounjaro.

  • Discover Healthon’s Compounded Tirzepatide: You can get this medicine only with proper support from a licensed doctor. Healthon offers a safe option with clear information about what goes into the drug. Read more about this here: Tirzepatide Product Information.

How Common Is Constipation With Mounjaro?

Constipation is a common side effect of Mounjaro. Clinical trials show that many users get this side effect when they take this medication. Knowing how often this happens can help people understand what to expect. It also gives them insight into what they might go through while using Mounjaro.

Data From Clinical Trials

The results from the SURPASS clinical trials gave important information about the safety and how well Mounjaro (tirzepatide) works. One of the common side effects found was constipation. This side effect showed up often for people who used it. The FDA label for Mounjaro clearly lists constipation as a possible side effect. This means people should know about it if they are starting their weight loss journey. Knowing about these results can help you understand what to expect and make it easier to talk to your healthcare provider about any stomach problems that come up during your weight loss.

How Long Does Constipation Last on Mounjaro?

Side effects can be very different for each person during the time when Mounjaro doses go up. The body needs time to get used to the active ingredient in it. Some people may have stomach problems, like being constipated or experiencing a loss of appetite. Others may find that their digestion gets better as time passes. 

Making small changes to your eating habits and diet, such as eating more frequently, smaller meals and drinking more water, can help improve these effects. Working with your doctor can help you find the best way to manage these sights. This can help you feel better and make your weight loss journey more comfortable as a Mounjaro user.

How to Relieve Constipation While Taking Mounjaro or Tirzepatide

Plate filled with nutrient-rich foods, symbolizing the role of a healthy, fiber-rich diet in managing Mounjaro-induced constipation and supporting digestive health.

Making some changes in your lifestyle and diet can help a lot with constipation for Mounjaro users. Adding more fiber from whole grains, fruit, and vegetables, along with drinking plenty of fluids and ensuring adequate water intake, helps the digestive system and supports regular bowel movements by promoting GI tract health. 

Taking part in gentle physical activity can also help your body work well, making constipation easier to manage.You might also use over-the-counter products like stool softeners or osmotic laxatives. It is important to talk with your doctor about your medical care before using any new medicine, especially if the problem does not get better or starts to get worse. This helps you stay safe while handling these side effects.

Lifestyle & Diet Changes

Making some changes to your lifestyle and diet can really help with constipation that comes with Mounjaro. Try to eat more fiber. Whole grains, fruits, and vegetables are good for this. They help your bowel movements get better.

You should also drink plenty of water. This is important because you need to stay hydrated for your digestive system to work well. Doing regular physical activity can also help your digestive system do its job. Moving your body will make things move along easier in your bowels.

It’s helpful to stay away from foods that can make constipation worse. These are things like processed snacks and dairy foods. These kinds of foods can upset your stomach and slow down your digestive system.

Keeping up with these changes will help you have a better and more comfortable weight loss journey. Eating whole grains and taking care of your body can make a big difference as you work on weight loss.

Safe Over-the-Counter Options

Osmotic laxatives like polyethylene glycol help with constipation. They pull water into the intestines, which makes the stool softer and easier to pass. Stool softeners such as docusate sodium can also be good for this. They help keep water in the stool, making the stool softer.

If you have ongoing or severe digestive problems or get severe abdominal pain while using Mounjaro for weight loss, talk to your doctor. Medical attention, including a visit to the emergency room, is needed if you get bad abdominal pain or constipation that lasts a long time, especially if you have conditions like severe gastroparesis or inflammation of the gallbladder. This can help your provider make changes to your treatment and lower the risks that can come with weight loss medicines.

Should You Stop Weight Loss Medications If You’re Constipated?

General practitioner speaking with a female patient during a checkup, emphasizing the value of professional medical guidance when addressing Mounjaro-related side effects like constipation.

It’s very important to talk openly with your healthcare provider if you notice side effects from Mounjaro. Do not stop taking the medicine on your own, as this can hurt your weight loss and your health. Some things like constipation may not last long, and you can handle them in different ways. 

Small changes in how you live and over-the-counter products can help you feel better. Always check with your provider to get advice made just for you. This will help keep your treatment safe and your weight loss journey on track. Your health and well-being come first.

If you are thinking about using weight loss medication, you might want to see how tirzepatide and semaglutide compare. These two medicines are popular when it comes to weight loss. Learning about their effects, what side effects they have, and how they might help you reach your goals can help you decide what is best for you. 

You can read a full guide here: Tirzepatide vs. Semaglutide: Which Weight Loss Drug Works Best?. It will help you know more about these weight loss treatments. This is useful if you want to move forward in your weight loss journey and want the right support with weight loss medication for your health plan.

We’re Here to Help!

Understanding the effects of Mounjaro is crucial for anyone navigating their weight loss journey. Symptoms like constipation can be temporary and manageable with proper lifestyle adjustments and medical guidance. 

Healthon is dedicated to supporting you 24/7, ensuring you have access to the resources and assistance you need. For any concerns or questions about Mounjaro, don’t hesitate to reach out. Additional support is just a click away at our contact page: Healthon Contact. Let's work together towards your health goals!

For those who want help with weight loss, Mounjaro (tirzepatide) could be a good choice in your weight loss journey. This new medicine helps you manage blood sugar and can help you lose weight. 

You should look at all parts of this treatment, like possible side effects such as constipation. If you want to know more about Mounjaro, and see how it can fit your health goals, visit Healthon's product page for more information that fits your needs about weight loss and blood sugar levels.

Frequently Asked Questions

Does Mounjaro cause constipation?

Yes, Mounjaro (tirzepatide) can make you constipated. It does this because it slows down gastric emptying in the stomach, and this is a common side effect seen in clinical trials. Not everyone will get this side effect, but you should watch out for symptoms. If you notice any problem, try to change your diet to help with relief.

How long does constipation from Mounjaro last?

Constipation from Mounjaro is different for each person. This can be more common during the time when your dose goes up. In rare cases, some people may have some pain for a short time. The problem can often get better as you and your body adjust, and if you follow some simple steps for help and change a few habits. Talk to your doctor to get good advice and support for these issues.

How do you treat constipation while on Mounjaro?

To help with constipation when taking Mounjaro, you can try some lifestyle changes. Increase the amount of fiber in your food and also drink more water. Make sure you keep up with daily physical activity, even if it is gentle. Try not to eat foods that can cause constipation. Some people also use stool softeners or laxatives from the store. But you should talk to your healthcare provider for advice that is right for you.

Reference List:

WEIGHT LOSS

Tirzepatide

From $275.00

WEIGHT LOSS

Tirzepatide

From $275.00

Achieve your weight loss goals with Tirzepatide—a dual-action medication that curbs appetite and regulates blood sugar. Lose up to 20% of your bodyweight supported by personalized medical care for safe, effective, and sustainable results.

Start My Health Journey

Weight Loss

Semaglutide

From $155.00

Weight Loss

Semaglutide

From $155.00

Achieve your weight loss goals with Semaglutide—a powerful GLP-1 medication that reduces hunger and helps regulate blood sugar. Lose up to 15% of your bodyweight with expert medical guidance for safe, effective, and long-term results.

Start My Health Journey
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