GLP-1 Receptor Agonists: Revolutionizing Weight Loss Strategies

Key Highlights

• GLP-1 receptor agonists are a class of medications initially developed for type 2 diabetes, now demonstrating impactful results for weight loss.

• These drugs work by mimicking a naturally occurring hormone, GLP-1, influencing appetite regulation, insulin release, and blood sugar levels.

• Options include short-acting and long-acting GLP-1 receptor agonists, providing dosing flexibility to align with an individual's lifestyle and preferences.

• Beyond weight management, this drug class offers additional health advantages, like reducing the risk of heart disease and improving blood sugar control in individuals with type 2 diabetes.

• Consulting a healthcare provider is crucial to determine if GLP-1 receptor agonists are a suitable treatment choice, considering individual health history and goals

Introduction

In the realm of obesity treatment and weight management, GLP-1 receptor agonists are emerging as a groundbreaking class of medications. These drugs, administered via injection, work by harnessing the power of naturally occurring hormones that regulate appetite and metabolism. This article will explore what GLP-1 receptor agonists are, how they function, and their potential benefits and considerations.

Understanding GLP-1 Receptor Agonists

GLP-1 receptor agonists are a relatively new class of drugs making significant strides in addressing obesity and type 2 diabetes. They function by mirroring the effects of glucagon-like peptide-1 (GLP-1), a hormone naturally produced in the body.

GLP-1 plays a crucial role in regulating appetite, blood sugar, and digestion. By activating GLP-1 receptors, these agonists effectively stimulate insulin production, lower blood sugar levels, slow gastric emptying, and promote a feeling of fullness - all of which contribute to weight loss.

The Science Behind GLP-1 and Weight Management

GLP-1, short for glucagon-like peptide-1, is a naturally occurring hormone produced in the small intestine in response to food intake. It plays a vital role in maintaining healthy body weight by influencing various physiological processes.

One of the key ways GLP-1 contributes to weight management is through its impact on appetite regulation. It acts on the brain, specifically the hypothalamus, to promote feelings of satiety and reduce hunger signals. This leads to a decrease in overall calorie intake, which is crucial for weight loss.

Furthermore, GLP-1 stimulates insulin release from the pancreas in a glucose-dependent manner. This means that insulin secretion is enhanced when blood sugar levels are high, such as after a meal. This targeted insulin release helps regulate blood glucose levels and prevents sharp spikes in blood sugar, which can contribute to weight gain.

Different Types of GLP-1 Receptor Agonists

Within the drug class of GLP-1 receptor agonists, there are several different medications available, each with its unique characteristics. While they share the same mechanism of action, subtle differences in their active ingredients and formulations result in variations in dosing schedules, potential side effects, and clinical outcomes.

Pharmaceutical companies have been actively involved in researching and developing new GLP-1 receptor agonists, leading to an expanding range of options for patients. Some of the commonly prescribed medications in this class include:

• Semaglutide (Ozempic, Wegovy, Rybelsus)

• Dulaglutide (Trulicity)

• Liraglutide (Victoza, Saxenda)

• Exenatide (Byetta, Bydureon)

These medications differ in their dosing frequency, ranging from once daily to once weekly, offering patients flexibility in managing their treatment regimen.

The Role of GLP-1 Receptor Agonists in Obesity Treatment

GLP-1 receptor agonists have emerged as a promising avenue in obesity treatment, marking a significant shift in how we approach weight management. Initially developed for type 2 diabetes, their remarkable ability to induce substantial weight loss has positioned them at the forefront of obesity care.

Clinicians are increasingly recognizing the value of GLP-1 receptor agonists in conjunction with lifestyle modifications to achieve and sustain healthy weight loss in individuals struggling with obesity. Their efficacy in not only promoting weight reduction but also improving metabolic health markers makes them a valuable tool in combating this complex chronic disease.

Mechanism of Action: How GLP-1 Receptor Agonists Work

GLP-1 receptor agonists work by imitating the effects of GLP-1, a naturally occurring hormone produced in the small intestine. When released after a meal, GLP-1 travels through the bloodstream and interacts with receptors found on various organs, including the pancreas and brain. This interaction triggers a cascade of physiological responses that contribute to weight loss.

One crucial action of GLP-1 receptor agonists is their ability to stimulate insulin secretion from the pancreas. Insulin is a hormone responsible for regulating blood glucose levels by allowing cells to absorb glucose from the bloodstream. By increasing insulin production, these medications help lower blood glucose levels, especially after meals.

Additionally, GLP-1 receptor agonists slow down gastric emptying, which means food remains in the stomach for a longer period. This delayed digestion promotes a feeling of fullness and reduces appetite, leading individuals to consume fewer calories and subsequently lose weight.

Efficacy of GLP-1 Receptor Agonists in Clinical Trials

Rigorous clinical trials have consistently demonstrated the impressive efficacy of GLP-1 receptor agonists in achieving significant weight loss. These trials, conducted on a large scale, have provided robust clinical data supporting their use as a valuable tool for weight management.

Studies have shown that individuals taking GLP-1 receptor agonists experience substantial weight loss results, often exceeding what can be achieved with lifestyle modifications alone. Furthermore, the weight loss observed is not only statistically significant but also clinically meaningful, leading to improvements in various health outcomes.

Beyond the reduction in body weight, clinical trials highlight the positive impact of GLP-1 receptor agonists on cardiovascular and metabolic health. They have been associated with improvements in blood pressure, blood sugar control, and lipid profiles, reducing the risk of developing or worsening associated health conditions.

Comparing GLP-1 Receptor Agonists

With the growing number of GLP-1 receptor agonists available, it's important to differentiate between these options to determine the most suitable choice for an individual. Factors such as dosing frequency, potential side effects, and overall cost can vary significantly.

The decision of which GLP-1 receptor agonist to prescribe is best made through a collaborative discussion between the patient and their healthcare provider. Factors such as medical history, lifestyle, and treatment goals should be carefully considered to ensure the chosen medication aligns with the patient's specific needs.

Short-Acting vs. Long-Acting: Benefits and Considerations

A significant distinction among GLP-1 receptor agonists lies in their duration of action, leading to the classification of short-acting and long-acting options. This difference in how long they remain active in the body directly translates to variations in dosing frequency, impacting the overall patient experience.

Short-acting GLP-1 receptor agonists typically require daily, or even twice-daily, injections, which can be a significant consideration for individuals seeking a less frequent dosing schedule. While more frequent injections may be perceived as inconvenient, they can offer tighter blood glucose control and potentially a faster onset of action.

On the other hand, long-acting GLP-1 receptor agonists provide the convenience of once-weekly dosing, making them an attractive option for many patients. This reduced injection frequency often leads to improved adherence to the treatment regimen and a more positive patient experience.

Key Players: Ozempic, Trulicity, Wegovy, and Others

The pharmaceutical market offers a diverse range of GLP-1 receptor agonists, with some notable key players gaining recognition for their effectiveness in weight management and diabetes treatment. Understanding the distinctions between these brands is crucial for both healthcare providers and patients.

Among the leading contenders are Ozempic and Wegovy, both containing the active ingredient semaglutide. While both medications utilize the same active ingredient, they are approved for different indications and are available in different dosages. Similarly, Trulicity, with its active ingredient dulaglutide, is another widely prescribed GLP-1 receptor agonist known for its once-weekly dosing regimen.

To provide a clearer comparison, here's a table highlighting key characteristics of some commonly prescribed GLP-1 receptor agonists:

Benefits of GLP-1 Receptor Agonists Beyond Weight Loss

Beyond their remarkable weight-loss benefits, GLP-1 receptor agonists exhibit a range of positive effects that extend to overall health and well-being. These medications offer benefits that go beyond simply shedding pounds, making them a valuable therapeutic option for individuals with specific health conditions.

Studies have shown that GLP-1 receptor agonists can improve cardiovascular health, reduce the risk of heart attacks and strokes, and improve blood sugar control in individuals with type 2 diabetes. These additional benefits, coupled with their weight management properties, make them a holistic approach to improving metabolic health.

Impact on Cardiovascular Health

Individuals struggling with obesity often face an increased risk of developing cardiovascular disease. The impact of GLP-1 receptor agonists on cardiovascular health extends beyond weight loss, demonstrating a protective effect against heart disease.

Clinical trials have consistently shown that GLP-1 receptor agonists can significantly reduce the risk of major adverse cardiovascular events, including heart attacks, strokes, and cardiovascular-related death. These medications work through various mechanisms to achieve this cardioprotective effect.

For instance, GLP-1 receptor agonists have been shown to lower blood pressure, improve cholesterol levels, and reduce inflammation, all of which are major contributors to cardiovascular disease. By addressing these risk factors, GLP-1 receptor agonists play a crucial role in mitigating cardiovascular risks.

Effects on Blood Sugar Levels and Diabetes Management

In addition to their weight-loss benefits, GLP-1 receptor agonists have demonstrated remarkable efficacy in improving blood sugar control for individuals with type 2 diabetes. These medications work by enhancing insulin secretion, suppressing glucagon release, and slowing gastric emptying, collectively contributing to improved glucose control.

By stimulating insulin production from the pancreas, GLP-1 receptor agonists help cells effectively utilize glucose from the bloodstream, preventing hyperglycemia. Simultaneously, they suppress the release of glucagon, a hormone that increases blood sugar levels.

Furthermore, GLP-1 receptor agonists enhance insulin sensitivity, meaning that cells become more responsive to the effects of insulin, further aiding in glucose regulation. This multifaceted approach to diabetes management makes them a valuable tool in achieving target blood sugar levels.

Potential Side Effects and Considerations

While generally considered safe for most individuals, GLP-1 receptor agonists, like any medication, come with potential side effects. Understanding these side effects is important for both patients and healthcare providers to ensure appropriate management and prompt intervention if needed.

Most side effects associated with GLP-1 receptor agonists are gastrointestinal in nature, including nausea, vomiting, diarrhea, and constipation. These side effects typically occur during the initiation of therapy and tend to subside with continued use as the body adjusts to the medication.

Common Side Effects and How to Manage Them

As with any medication, GLP-1 receptor agonists can cause side effects, with the most common being gastrointestinal in nature. These can include:

• Nausea: This is perhaps the most frequently reported side effect, often occurring during the initial weeks of treatment.

• Vomiting: Although less common, some individuals experience vomiting, especially with higher doses.

• Diarrhea: This side effect can range in severity from mild to moderate and is often temporary.

• Constipation: A less common side effect, constipation may occur in some individuals.

Fortunately, most of these side effects can be effectively managed with simple adjustments to the treatment regimen or lifestyle changes. Starting with a lower dose and gradually increasing it can help minimize the initial gastrointestinal discomfort. Staying hydrated, eating smaller, more frequent meals, and avoiding trigger foods can also help alleviate these side effects.

When to Consult a Healthcare Provider

While GLP-1 receptor agonists are generally considered safe, it's essential to be aware of potential adverse effects and seek medical attention promptly if needed. Open communication with your healthcare provider is crucial throughout your treatment journey.

If you experience severe or persistent side effects, such as severe abdominal pain, intractable vomiting, or signs of an allergic reaction, it's important to seek immediate medical attention. Do not hesitate to contact your healthcare provider if you have any concerns about your treatment.

Remember, your healthcare provider is your best resource for managing any side effects and ensuring your safety and well-being while taking GLP-1 receptor agonists. Regular check-ups and open communication are paramount for successful treatment outcomes.

Patient Success Stories

Real-life experiences of individuals who have incorporated GLP-1 receptor agonists into their weight loss journeys highlight the transformative potential of these medications. These success stories provide a glimpse into the positive impact these medications can have on health, well-being, and quality of life.

Many individuals share inspiring accounts of achieving significant weight loss, witnessing improvements in blood sugar control, and experiencing a renewed sense of vitality after starting GLP-1 receptor agonists. Such narratives not only provide hope but also underscore the importance of personalized treatment plans tailored to individual needs.

Real-Life Weight Loss Journeys with GLP-1 Receptor Agonists

Countless individuals have embarked on life-changing weight loss journeys with the help of GLP-1 receptor agonists. Their personal anecdotes serve as powerful testaments to the effectiveness of these medications in achieving sustainable weight loss.

Sarah, a 42-year-old woman who had struggled with obesity for years, found renewed hope after incorporating a GLP-1 receptor agonist into her weight loss plan. Alongside lifestyle changes, the medication helped her shed excess weight, significantly improving her energy levels and overall quality of life.

Similarly, John, a 55-year-old man diagnosed with type 2 diabetes, experienced remarkable improvements in his blood sugar control after starting a GLP-1 receptor agonist. The medication not only helped him lose weight but also lowered his blood sugar levels to a healthy range, reducing his dependence on additional diabetes medications.

How GLP-1 Receptor Agonists Changed Lives

The transformative effects of GLP-1 receptor agonists extend far beyond the physical realm. Patient testimonials reveal profound improvements in quality of life, self-esteem, and overall well-being. These medications empower individuals to regain control over their health and embrace a more fulfilling life.

Many individuals share how their weight loss achievements have led to increased confidence, improved mobility, and a renewed sense of vitality. The ability to engage in activities they once found challenging, wear clothes they had longed to fit into, and simply feel more comfortable in their bodies has significantly enhanced their quality of life.

Furthermore, the positive impact of GLP-1 receptor agonists on blood sugar control for individuals with diabetes has been life-changing. Many patients report reduced worries about diabetes-related complications, increased energy levels, and a greater sense of control over their health.

Navigating Your Options: Finding the Right GLP-1 Receptor Agonist

With a growing number of GLP-1 receptor agonists available, selecting the most appropriate option can seem daunting. However, by carefully considering several factors and engaging in open communication with your healthcare provider, you can determine the best medication to meet your individual needs.

Factors such as medical history, lifestyle preferences, potential side effects, cost, and insurance coverage all play a role in the decision-making process. A collaborative approach, involving a thorough discussion with your healthcare provider, is essential for making an informed choice.

Factors to Consider When Choosing a GLP-1 Receptor Agonist

Several factors come into play when selecting the most suitable GLP-1 receptor agonist for an individual. Drug efficacy, while a primary consideration, should be assessed alongside other crucial aspects, including the side effect profile, patient preferences, and individual health circumstances.

Each GLP-1 receptor agonist exhibits a unique side effect profile, with variations in the type, frequency, and severity of potential adverse events. Some individuals may prioritize medications with a lower risk of gastrointestinal side effects, while others might prioritize those with a proven track record of cardiovascular benefits.

Patient preferences play a pivotal role in ensuring adherence to the treatment regimen. Factors such as dosing frequency, injection device, and potential for weight loss or blood sugar control should be carefully considered.

Consulting with Healthcare Professionals

Navigating the complexities of GLP-1 receptor agonist therapy requires expert guidance from a qualified healthcare provider. Consulting with your doctor or a registered dietitian specializing in weight management is crucial for determining the appropriateness of these medications for your individual needs.

Your healthcare provider will conduct a comprehensive health assessment, considering factors such as your medical history, current medications, lifestyle, and treatment goals. Based on this assessment, they can provide personalized medical advice tailored to your specific circumstances.

Together, you and your healthcare provider will develop a comprehensive treatment plan that addresses your weight loss or diabetes management goals while considering potential side effects, necessary monitoring, and expected outcomes. This collaborative approach is essential for ensuring safe and effective treatment.

Insurance Coverage and Access to GLP-1 Receptor Agonists

Insurance coverage for GLP-1 receptor agonists can vary significantly depending on factors such as the specific medication, the insurance plan, and the individual's medical history. Navigating these complexities can be challenging and often requires persistence and advocacy.

Understanding your insurance policy and its coverage for weight loss medications is crucial. Contacting your insurance provider directly can provide clarity on which medications are covered, what documentation is required for prior authorization, and what out-of-pocket expenses you may incur.

Understanding Insurance Policies and Coverage

Navigating the world of medical insurance and prescription drug coverage can be daunting, especially when it comes to specialized medications like GLP-1 receptor agonists. Understanding your insurance policy's specifics regarding weight loss medications is essential.

Insurance coverage for GLP-1 receptor agonists varies widely depending on the insurance provider, the specific plan, and the individual's medical history. Some insurance plans may require prior authorization before approving coverage, which involves providing medical documentation to demonstrate the medical necessity of the medication.

It's important to contact your insurance provider directly to inquire about their coverage policies for weight loss medications, including GLP-1 receptor agonists. Their representatives can help you understand the specific requirements for coverage, potential reimbursement limitations, and any out-of-pocket costs you might incur.

Assistance Programs and Affordability Solutions

The cost of GLP-1 receptor agonists can be a significant barrier for many individuals seeking to improve their health and well-being. However, several patient assistance programs and cost-saving measures are available to help alleviate this financial burden.

Many pharmaceutical companies offer patient assistance programs that provide financial support for eligible individuals who are unable to afford their medications. These programs often have specific eligibility criteria, such as income level and insurance status.

Additionally, exploring options such as manufacturer coupons, discount cards, and pharmacy savings programs can help reduce the out-of-pocket expenses associated with GLP-1 receptor agonists. Consulting with a healthcare advocate or social worker can provide valuable guidance on navigating these resources.

Lifestyle Changes to Enhance the Effectiveness of GLP-1 Receptor Agonists

While GLP-1 receptor agonists are potent tools for weight loss and diabetes management, they are most effective when combined with sustainable lifestyle changes. Integrating these medications into a holistic approach that encompasses dietary modifications and regular physical activity is crucial for maximizing their benefits.

Adopting a balanced and nutritious diet that prioritizes whole foods, fruits, vegetables, lean proteins, and healthy fats, alongside portion control, forms the cornerstone of successful weight management. Coupled with regular exercise, this multi-pronged strategy can amplify the effects of GLP-1 receptor agonists.

Diet and Nutrition Considerations

Optimizing your diet and nutrition is paramount when incorporating GLP-1 receptor agonists into your weight loss or diabetes management plan. Making mindful choices about your calorie intake, seeking professional nutritional counseling, and adopting healthy dietary habits can significantly enhance the effectiveness of these medications.

Working with a registered dietitian can provide personalized guidance on creating a balanced and sustainable meal plan tailored to your unique needs and preferences. They can help you make informed choices about food portions, nutrient timing, and calorie intake to support your weight loss or blood sugar goals.

Additionally, focusing on nutrient-dense foods, such as fruits, vegetables, lean proteins, and whole grains, can help you feel more satiated and reduce cravings while providing essential vitamins and minerals. Staying adequately hydrated by drinking plenty of water throughout the day is also crucial for optimal health.

The Importance of Physical Activity

Engaging in regular physical activity is an integral part of a comprehensive weight loss or diabetes management strategy, amplifying the beneficial effects of GLP-1 receptor agonists. Incorporating an exercise regimen that aligns with your fitness level and preferences offers a myriad of metabolic benefits and supports long-term success.

Physical activity not only increases energy expenditure, aiding in calorie burning and weight loss, but also improves insulin sensitivity. This enhanced insulin sensitivity allows your body to utilize glucose more effectively, leading to better blood sugar control and reducing the risk of diabetes complications.

Finding activities you enjoy, whether it's brisk walking, dancing, swimming, or cycling, can make incorporating exercise into your routine more sustainable and enjoyable. Gradually increasing the intensity and duration of your workouts over time can lead to even greater health benefits.

The Future of GLP-1 Receptor Agonists in Weight Loss

The field of GLP-1 receptor agonist therapy is continuously evolving, with ongoing clinical studies and research paving the way for exciting new developments. These advancements hold immense promise for revolutionizing weight loss strategies in the years to come.

Researchers are exploring novel applications of GLP-1 receptor agonists, investigating their potential in addressing other obesity-related conditions and metabolic disorders. Additionally, efforts are underway to develop new formulations and delivery methods to further enhance convenience and patient experience.

Emerging Research and New Developments

The future of GLP-1 receptor agonists in weight loss is bright, with ongoing clinical studies and innovative research continuously expanding their therapeutic potential. Scientists and pharmaceutical companies are diligently working to develop new generations of these medications with enhanced efficacy, fewer side effects, and greater accessibility.

Current clinical studies are investigating the use of GLP-1 receptor agonists in combination with other anti-obesity medications to explore synergistic effects and potentially further enhance weight loss outcomes. Additionally, research is underway to develop new formulations, such as oral or transdermal delivery methods, to improve patient convenience and adherence to treatment.

This continuous innovation in the field of GLP-1 receptor agonists underscores their significant role in shaping the future of weight loss treatments and improving the lives of millions struggling with obesity.

The Next Generation of GLP-1 Receptor Agonists

Scientists are tirelessly working on developing the next generation of GLP-1 receptor agonists, leveraging breakthroughs in peptide analogs and pharmacological advancements to unlock even greater therapeutic potential. These cutting-edge medications hold the promise of addressing unmet needs and improving outcomes for individuals with obesity and related conditions.

One area of focus is creating longer-acting GLP-1 receptor agonists that require less frequent dosing, potentially improving patient adherence and convenience. Additionally, researchers are investigating ways to enhance the selectivity of these medications, targeting specific GLP-1 receptor subtypes to maximize therapeutic benefits while minimizing potential side effects.

Furthermore, the development of dual-acting or triple-acting medications, combining GLP-1 receptor agonists with other weight-loss agents, aims to provide a more comprehensive and personalized approach to obesity treatment. These advancements reflect the ongoing commitment to pushing the boundaries of therapeutic possibilities in the fight against obesity.

Conclusion

GLP-1 receptor agonists are reshaping weight loss strategies with their proven efficacy and multifaceted benefits. By delving into the science behind these agents, understanding their mechanisms, and exploring their impact on various health aspects, individuals can make informed decisions about their weight management journey. Patient success stories underscore the transformative power of GLP-1 receptor agonists, offering hope and inspiration. Navigating treatment options, lifestyle modifications, and future advancements ensures a comprehensive approach to sustainable weight loss. With healthcare providers' guidance and tailored solutions, embracing these innovative therapies can pave the way for healthier, fulfilling lives. Trust in the potential of GLP-1 receptor agonists to revolutionize your weight loss endeavors.

Frequently Asked Questions

How does Healthon’s Weight Loss Programs work?

1. Complete a Medical Intake Form: Upon registering, you will be asked to fill out a detailed medical intake form, which gathers your health history and relevant information about your weight loss goals.
2. Review by a Physician: Once your intake form is submitted, one of Healthon’s licensed physicians will review your information to determine your medical eligibility for the program. Depending on your state’s telehealth regulations, this review will be conducted either through a SYNC (live) or ASYNC (offline) telehealth visit.
3. Approval and Notification: If you are approved, you will receive a notification of your eligibility for the program, and your prescription for either Semaglutide or Tirzepatide will be issued.
4. Medication Shipment: Once your prescription is approved, your medication will be shipped directly to your home. You will receive tracking information to monitor the delivery..

How long will it take to see results with the Healthon Weight Loss Program?

Results from the Healthon Weight Loss Program vary depending on the individual, but most patients begin to see noticeable weight loss within the first 4-12 weeks of treatment. GLP-1 medications like Semaglutide and Tirzepatide are typically administered once weekly, and gradual, sustained weight loss occurs over several months.
On average, patients experience:
• 5-10% weight loss within the first 3 months.
• Up to 15-22% weight loss after 6-12 months of continuous use.
Consistency in treatment, along with lifestyle changes such as diet and physical activity, can further enhance and maintain weight loss.

Are there any long-term risks associated with using GLP-1 receptor agonists?

Most side effects are mild and tend to subside over time, but more serious side effects may occur in rare cases.

Common Side Effects:
• Nausea: This is the most common side effect and usually occurs when starting the medication or after increasing the dose. It generally improves over time.
• Vomiting
• Diarrhea
• Constipation
• Indigestion
• Decreased appetiteLess Common but Serious Side Effects:
• Hypoglycemia (low blood sugar): Especially when used in combination with other diabetes medications like insulin.
• Pancreatitis: In rare cases, GLP-1 medications have been associated with inflammation of the pancreas.
• Gallbladder issues: Including gallstones.
• Kidney problems: May lead to dehydration and worsen kidney function in patients with pre-existing kidney conditions.

Injection Site Reactions:
• Redness or irritation at the injection site is possible but usually mild.

Are there any side effects associated with GLP-1 medications (Semaglutide and Tirzepatide)?

Consulting with a healthcare provider is essential to determine if you are a suitable candidate for a GLP-1 receptor agonist. They will conduct a health assessment, considering your medical history, treatment objectives, and overall health status to make an informed recommendation.

Reference List

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2. Mayo Clinic. (n.d.). GLP-1 and Blood Sugar Regulation. Available at: https://www.mayoclinic.org/diseases-conditions/type-2-diabetes/expert-answers/byetta/faq-20057955

3. UChicago Medicine. (n.d.). Research on GLP-1 Drugs. Available at: https://www.uchicagomedicine.org/forefront/research-and-discoveries-articles/research-on-glp-1-drugs

4. Harvard Health. (n.d.). GLP-1 and Weight Loss. Available at: https://www.health.harvard.edu/staying-healthy/glp-1-diabetes-and-weight-loss-drug-side-effects-ozempic-face-and-more

5. Wolters Kluwer. (n.d.). GLP-1 Medications and Weight Loss. Available at: https://www.wolterskluwer.com/en/expert-insights/glp-1-medications-and-weight-loss-help-patients-navigate-beyond-trends